1,2,3-Trisubstituted Indanes by Highly Diastereoselective Palladium-Catalyzed Oxyarylation of Indenes with Arylboronic Acids and Nitroxides

Kirchberg S, Frohlich R, Studer A

Zusammenfassung

Excellent stereoselectivity is obtained in the synthesis of biologically interesting 1,2,3-trisubstituted indanes B by the reaction of readily prepared 3-substituted indenes A with commercially available arylboronic acids by using various TEMPO derivatives as external oxidants and Pd(OAc)2 as a catalyst. The anti,anti isomers are formed and reactions occur stereospecifically under mild conditions.