Efficient synthesis of 1-deaza-6-methoxypurine-N9-beta-2’-deoxyribonucleoside and related DNA building blocks
Megger DA, Müller J
Research article (journal) | Peer reviewedAbstract
An improved synthesis of the 2′-deoxyribonucleoside containing 1-deaza-6-methoxypurine as artificial nucleobase is described. By optimizing the conditions for the deprotection of p-toluoyl-protected 1-deaza-6-nitropurine 2′-deoxyribonucleoside, the isolated yield of the title compound could be increased from 15% to 90%. In addition, the synthesis and characterization of the corresponding 5′-(4,4′-dimethoxytrityl)(DMT) protected phosphoramidite, a potentially useful building block for the synthesis ofartificial oligonucleotides, is reported. The title compound offers interesting hydrogen bond donor and metal-binding properties for its application in metal-mediated base pairs.© Taylor &Francis Group, LLC.
Details about the publication
Journal: Synthetic Communications
Volume: 41
Page range: 2524-2529
Status: Published
Release year: 2011 (21/06/2011)
Language in which the publication is written: English
Keywords: synthesis; 1-deaza-6-methoxypurine-N9-beta-2’-deoxyribonucleoside; DNA
Authors from the University of Münster
| Megger, Dominik | Institute of Inorganic and Analytical Chemistry |
| Müller, Jens | Professorship of Inorganic Chemistry (Prof. Müller) |
Projects the publication originates from
Duration: 18/07/2006 - 31/07/2011 | 1st Funding period Funded by: DFG - International Research Training Group Type of project: Main DFG-project hosted at University of Münster |