Paracetamol for perioperative analgesia. Old substance - new insights.
Zahn PK, Sabatowski R, Schug SA, Stamer UM, Pogatzki-Zahn EM
Research article (journal)Abstract
Since paracetamol was first synthesized in 1878 it has become one of the most popular and widely used drugs for the first-line treatment of fever and pain. The reasons for this popularity are a wide variety of formulations, an assumed positive safety record and the wide availability as an over-the-counter drug. However, recently several studies questioned the positive risk-benefit ratio of paracetamol for postoperative pain by observing several possible adverse effects and limitations. The aim of the present review is to give an update of the recent literature on the efficacy of paracetamol for postoperative pain and on the value of the clinical relevance of different adverse effects of paracetamol. Finally, based on the current findings the authors try to assess the role of paracetamol for the treatment of postoperative pain.
Details about the publication
Authors from the University of Münster
| Pogatzki-Zahn, Esther | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
| Zahn, Peter | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |