Paracetamol for perioperative analgesia. Old substance - new insights.

Zahn PK, Sabatowski R, Schug SA, Stamer UM, Pogatzki-Zahn EM

Forschungsartikel (Zeitschrift)

Zusammenfassung

Since paracetamol was first synthesized in 1878 it has become one of the most popular and widely used drugs for the first-line treatment of fever and pain. The reasons for this popularity are a wide variety of formulations, an assumed positive safety record and the wide availability as an over-the-counter drug. However, recently several studies questioned the positive risk-benefit ratio of paracetamol for postoperative pain by observing several possible adverse effects and limitations. The aim of the present review is to give an update of the recent literature on the efficacy of paracetamol for postoperative pain and on the value of the clinical relevance of different adverse effects of paracetamol. Finally, based on the current findings the authors try to assess the role of paracetamol for the treatment of postoperative pain.

Details zur Publikation

FachzeitschriftDer Anaesthesist
Jahrgang / Bandnr. / Volume59
Ausgabe / Heftnr. / Issue10
Seitenbereich940-952
StatusVeröffentlicht
Veröffentlichungsjahr2010
Sprache, in der die Publikation verfasst istDeutsch
DOI10.1007/s00101-010-1773-z

Autor*innen der Universität Münster

Pogatzki-Zahn, Esther
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Zahn, Peter
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie