University of Münster
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CRC 1009 A03 - Immune-cell interactions with endothelial cells and pericytes at the blood-brain-barrier: Mechanisms and consequences

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period

Description

Dieses Projekt charakterisiert die Rolle des ko-inhibitorischen B7-Homologs 1 (B7-H1)/PD1 Signalweges an der Blut-Hirn-Schranke sowie bei der ZNS Inflammation. Unsere bisherigen Daten zeigen dass B7-H1 ZNS Autoimmunität über 2 wesentliche Mechanismen kontrolliert: 1) über die Beeinflussung von T-Zell Mobilität/Motilität über zelluläre Barrieren sowie 2) über die Modulation der Th17 Differenzierung über einen bislang nicht identifizierten non-PD1-Rezeptor. Unser Projekt beantwortet die Frage wie B7-H1 zur Erhaltung von Toleranz gegen ZNS-Antigene beiträgt und den Zusammenbruch der Blut-Hirn-Schranke sowie die Entstehung entzündlicher Läsionen beeinflusst.

Keywords: Molekulare Neurologie; Zelluläre Neurologie; Neuropathologie
Website of the project: https://campus.uni-muenster.de/de/sfb-1009/projekte/projektbereich-a/a-03/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222612695
Funding identifier: SFB 1009/2 | DFG project number: 194468054
Funder / funding scheme: 
  • DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Klotz, Luisa Hildegard
Department for Neurology
Wiendl, Heinz Siegfried
Department for Neurology

Applicants from the University of Münster

Klotz, Luisa Hildegard
Department for Neurology
Wiendl, Heinz Siegfried
Department for Neurology

Projects of the previous funding period

SFB 1009 A03 - The role of coinhibitory signals of the B7/CD28 family in breaching the blood-brain-barrier and modulating neuroinflammation
Duration: 01/07/2012 - 30/06/2016 | 1st Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted at University of Münster

Projects of the following funding period

CRC 1009 - A03: Mechanisms and consequences of immune-cell interactions with endothelial cells and pericytes at the blood-brain-barrier
Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

SFB 1009 - Breaking Barriers - Immune cells and pathogens at cell / matrix barriers (SFB 1009/2)
Duration: 01/07/2016 - 30/06/2020 | 2nd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Main DFG-project hosted at University of Münster