CRC 1009 A03 - Mechanisms and consequences of immune-cell interactions with endothelial cells and pericytes at the blood-brain-barrier
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period
Description
Our project deals with the interactions of invading immune cells with the cellular components of the blood-brain-barrier in the context of neuroinflammation. We will study interactions between human immune cells and iPS cell-derived brain endothelial cells from patients suffering from distinct neuroinflammatory diseases, and study the consequences of in vivo transfer of human immune cells in a humanized mouse model. Furthermore, we will elucidate the role of pericyte loss or dysfunction for blood-brain-barrier integrity, chronic inflammation and demyelination.
Keywords: Molecular and Cellular Neurology; Neuropathology; Neuroimmunology
Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-03.html
Funding identifier: SFB 1009/3, A03
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Klotz, Luisa Hildegard | Department for Neurology |
| Wiendl, Heinz Siegfried | Department for Neurology |
Applicants from the University of Münster
| Klotz, Luisa Hildegard | Department for Neurology |
| Wiendl, Heinz Siegfried | Department for Neurology |