CRC 1009 - A03: Mechanisms and consequences of immune-cell interactions with endothelial cells and pericytes at the blood-brain-barrier
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period
Description
Our project deals with the interactions of invading immune cells with the cellular components of the blood-brain-barrier in the context of neuroinflammation. We will study interactions between human immune cells and iPS cell-derived brain endothelial cells from patients suffering from distinct neuroinflammatory diseases, and study the consequences of in vivo transfer of human immune cells in a humanized mouse model. Furthermore, we will elucidate the role of pericyte loss or dysfunction for blood-brain-barrier integrity, chronic inflammation and demyelination.
Keywords: Molecular and Cellular Neurology; Neuropathology; Neuroimmunology
Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-03.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222612695
Funding identifier: SFB 1009/3, A03 | DFG project number: 194468054
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Klotz, Luisa Hildegard | |
| Wiendl, Heinz Siegfried |
Applicants from the University of Münster
| Klotz, Luisa Hildegard | |
| Wiendl, Heinz Siegfried |
Projects of the previous funding period
Duration: 01/07/2016 - 30/06/2020 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |