University of Münster
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CRC 1009 B02 - The role of MAPK in influenza virus (IV) replication and bacterial super-infection

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period

Description

Invasion of influenza viruses (IV) and/or Staphylococcus aureus into cells of epithelial and endothelia barriers results in the activation of the Raf/MEK/ERK kinase cascade. It was previously shown that active ERK promotes nuclear export of IV genomes thereby supporting viral replication. The detailed mechanisms will now be further elucidated. Furthermore, regulation and function of the ERK pathway upon IV and/or S. aureus infection will be explored with respect to changes in immune responses, inflammation and pathogen load. Finally, suitability of the pathway as a target for anti-pathogen therapy will be evaluated.

Keywords: Molecular virology; signalling; influenza virus; Inflammation
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-02/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222660511
Funding identifier: SFB 1009/2 | DFG project number: 194468054
Funder / funding scheme: 
  • DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Ehrhardt, Christina
Institute of Virology
Ludwig, Stephan
Institute of Virology

Applicants from the University of Münster

Ehrhardt, Christina
Institute of Virology
Ludwig, Stephan
Institute of Virology

Projects of the previous funding period

SFB 1009 B02 - MAP Kinase Cascades and Influenza Virus Infection
Duration: 01/07/2012 - 30/06/2016 | 1st Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted at University of Münster

Projects of the following funding period

CRC 1009 - B02: The role of MAPK pathways in influenza virus replication and bacterial super-infection
Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

SFB 1009 - Breaking Barriers - Immune cells and pathogens at cell / matrix barriers (SFB 1009/2)
Duration: 01/07/2016 - 30/06/2020 | 2nd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Main DFG-project hosted at University of Münster