CRC 1009 B02 - The role of MAPK in influenza virus (IV) replication and bacterial super-infection
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
Invasion of influenza viruses (IV) and/or Staphylococcus aureus into cells of epithelial and endothelia barriers results in the activation of the Raf/MEK/ERK kinase cascade. It was previously shown that active ERK promotes nuclear export of IV genomes thereby supporting viral replication. The detailed mechanisms will now be further elucidated. Furthermore, regulation and function of the ERK pathway upon IV and/or S. aureus infection will be explored with respect to changes in immune responses, inflammation and pathogen load. Finally, suitability of the pathway as a target for anti-pathogen therapy will be evaluated.
Keywords: Molecular virology; signalling; influenza virus; Inflammation
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-02/
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Ehrhardt, Christina | Institute of Molecular Virology |
| Ludwig, Stephan | Institute of Molecular Virology |
Applicants from the University of Münster
| Ehrhardt, Christina | Institute of Molecular Virology |
| Ludwig, Stephan | Institute of Molecular Virology |