CRC 1009 A02 - Mechanisms of leukocyte penetration of vascular cell basement membranes
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
Laminin isoform composition (laminins 411 and 511) of endothelial basement membranes defines sites of leukocyte extravasation. Laminins can directly affect immune cell migration but can also effect the expression (CD99L2) and localization of endothelial junctional molecules (VE-cadherin) involved in paracellular migration. Signal cascades induced by laminins 411 and 511 in different immune cell populations will be studied and how this affects their migratory behaviours, and molecular mechanisms of laminin 511 affects on endothelial adhesion molecule expression and/or function.
Keywords: Matrix biology; immunology; Cell Biology
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-02/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222611976
Funding identifier: SFB 1009/2 | DFG project number: 194468054
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Sorokin, Lydia |
Applicants from the University of Münster
| Sorokin, Lydia |
Projects of the previous funding period
Duration: 01/07/2012 - 30/06/2016 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Projects of the following funding period
Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/07/2016 - 30/06/2020 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |