CRC 1009 A02 - Mechanisms of leukocyte penetration of vascular cell basement membranes
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
Laminin isoform composition (laminins 411 and 511) of endothelial basement membranes defines sites of leukocyte extravasation. Laminins can directly affect immune cell migration but can also effect the expression (CD99L2) and localization of endothelial junctional molecules (VE-cadherin) involved in paracellular migration. Signal cascades induced by laminins 411 and 511 in different immune cell populations will be studied and how this affects their migratory behaviours, and molecular mechanisms of laminin 511 affects on endothelial adhesion molecule expression and/or function.
Keywords: Matrix biology; immunology; Cell Biology
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-02/
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Sorokin, Lydia | Institute of Physiological Chemistry and Pathobiochemistry |
Applicants from the University of Münster
| Sorokin, Lydia | Institute of Physiological Chemistry and Pathobiochemistry |