CRC 1009 B03 - Autopenetrating bacterial effector proteins and modulation of signaling responses in cellular barriers
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
We have identified several T3SS-effectors of Gram-negative pathogens as 'cell-penetrating effector proteins (CPE)'. CPE derived from E. coli, Yersinia, and Shigella will be characterized for cellular uptake, intracellular trafficking, modulation of signaling pathways, their possibilities for heterologous cargo transport, and their effects on cellular barriers with and without shear stress under flow in 2-D and 3-D models. Furthermore, we will address potential therapeutic options in murine models of autoimmune diseases.
Keywords: Infection biology; E. coli; autoimmune diseases
Website of the project: https://campus.uni-muenster.de/de/sfb-1009/projekte/projektbereich-b/b-03/
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Rüter, Christian | Institute of Infectiology |
| Schmidt, M. Alexander | Institute of Infectiology |
Applicants from the University of Münster
| Rüter, Christian | Institute of Infectiology |
| Schmidt, M. Alexander | Institute of Infectiology |