CRC 1009 B04 - The bacterial secreted combinome: Synergistic host injury by exotoxins of enterohemorrhagic Escherichia coli
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
Enterohemorrhagic Escherichia coli (EHEC) secrete a cocktail of exotoxins, which in concert breach the intestinal epithelial and endothelial barrier, and cause severe complications such as the hemolytic uremic syndrome. This project is aimed at unraveling the interplay of virulence factors of EHEC serotypes O157:H- and O104:H4 and the role that host factors play in this process. Understanding the interactions of the individual determinants could form the basis for developing preventive and specific therapeutic measures for EHEC infections.
Keywords: EHEC; hämolytisch urämische Syndrom; HUS; Virulenzfaktoren; Infektiosnforschung
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-04/
Funding identifier: SFB 1009/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Mellmann, Alexander | Institute of Hygiene |
Applicants from the University of Münster
| Mellmann, Alexander | Institute of Hygiene |