CRC 1009 B04 - The bacterial secreted combinome: Synergistic host injury by exotoxins of enterohemorrhagic Escherichia coli
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 30/06/2020 | 2nd Funding period
Description
Enterohemorrhagic Escherichia coli (EHEC) secrete a cocktail of exotoxins, which in concert breach the intestinal epithelial and endothelial barrier, and cause severe complications such as the hemolytic uremic syndrome. This project is aimed at unraveling the interplay of virulence factors of EHEC serotypes O157:H- and O104:H4 and the role that host factors play in this process. Understanding the interactions of the individual determinants could form the basis for developing preventive and specific therapeutic measures for EHEC infections.
Keywords: EHEC; hämolytisch urämische Syndrom; HUS; Virulenzfaktoren; Infektiosnforschung
Website of the project: https://campus.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-04/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222661240
Funding identifier: SFB 1009/2 | DFG project number: 194468054
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Mellmann, Alexander |
Applicants from the University of Münster
| Mellmann, Alexander |
Projects of the previous funding period
Duration: 01/07/2012 - 30/06/2016 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Projects of the following funding period
Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/07/2016 - 30/06/2020 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |