EXC 1003 A6 - Motion Analysis in Cellular Systems

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/11/2012 - 31/10/2019 | 1st Funding period

Description

Manual methods for the analysis and interpretation of cellular and subcellular dynamics are often not feasible due to the large amount of data generated, visual limitations in 3D and the complexity of the processes analysed. Automated image analysis and mathematical modelling are required and will be covered in this project, which can be understood as a quantitative/mathematical implementation of the CiM concept. The central goal is to establish novel ways to connect imaging data with advanced mathematical modelling approaches, which will also be used to gain insight in cases where direct experimental investigations are not feasible. The focus will be on the development of advanced techniques for tracking moving immune and germ cells, their dynamic shape changes and intracellular processes based on the various imaging data acquired. The methodological advancements (mathematical and computational) will be driven by close interdisciplinary collaborations within CiM. Important aims are the establishment of paradigms for the simultaneous analysis of cell migration and phenotypic changes, improved automated image analysis and the implementation of mathematical modelling as a fundamental tool to qualitatively and quantitatively describe imaging data.

Keywords: Motion Analysis

Website of the project: http://www.uni-muenster.de/Cells-in-Motion/research/areaA/A.6.php

Funding identifier: EXC1003/1

Funder / funding scheme:

DFG - Cluster of Excellence (EXC)

Project management at the University of Münster

Burger, Martin	Professorship for applied mathematis, especially numerics (Prof. Burger)
Engwer, Christian	Professorship for Applications of Partial Differential Equations
Gorlatch, Sergei	Professorship of Practical Comupter Science (Prof. Gorlatch)
Jiang, Xiaoyi	Professur für Praktische Informatik (Prof. Jiang)
Ohlberger, Mario	Professorship of Applied Mathematics, especially Numerics (Prof. Ohlberger)
Raz, Erez	Institute of Cell Biology
Schwab, Albrecht	Institute of Physiology II
Vestweber, Dietmar	Max Planck Institute for Molecular Biomedicine

Applicants from the University of Münster

Burger, Martin	Professorship for applied mathematis, especially numerics (Prof. Burger)
Engwer, Christian	Professorship for Applications of Partial Differential Equations
Gorlatch, Sergei	Professorship of Practical Comupter Science (Prof. Gorlatch)
Jiang, Xiaoyi	Professur für Praktische Informatik (Prof. Jiang)
Ohlberger, Mario	Professorship of Applied Mathematics, especially Numerics (Prof. Ohlberger)
Raz, Erez	Institute of Cell Biology
Schwab, Albrecht	Institute of Physiology II
Vestweber, Dietmar	Max Planck Institute for Molecular Biomedicine

Related main project

EXC 1003 Cells in Motion - Imaging to Understand Cellular Behaviour in Organisms (CIM)

Duration: 01/11/2012 - 31/10/2019 | 1st Funding period

Funded by: DFG - Cluster of Excellence

Type of project: Main DFG-project hosted at University of Münster

Publications of the University of Münster resulting from the project

Data-driven combined state and parameter reduction for inverse problems Himpe C, Ohlberger M (2015) In: Advances in Computational Mathematics, 41(5), 1343-1364. doi:10.1007/s10444-015-9420-5 Research article (journal) \| Peer reviewed \| Published
Model Reduction for Complex Hyperbolic Networks Himpe C, Ohlberger M (2014) In: (eds.), , 2739-2743. Wiley-IEEE Press. doi:10.1109/ECC.2014.6862188 Research article in edited proceedings (conference) \| Peer reviewed \| Published
Cross-Gramian Based Combined State and Parameter Reduction for Large-Scale Control Systems Himpe C, Ohlberger M (2014) In: Mathematical Problems in Engineering, 2014, 1-13. doi:10.1155/2014/843869 Research article (journal) \| Peer reviewed \| Published
A Unified Software Framework for Empirical Gramians Himpe C, Ohlberger M (2013) In: ((Bitte Journal prüfen)), 2013(2013), 1-6. doi:10.1155/2013/365909 Research article (journal) \| Peer reviewed \| Published

Data-driven combined state and parameter reduction for inverse problems Himpe C, Ohlberger M (2015) In: Advances in Computational Mathematics, 41(5), 1343-1364. doi:10.1007/s10444-015-9420-5 Research article (journal) \| Peer reviewed \| Published
Model Reduction for Complex Hyperbolic Networks Himpe C, Ohlberger M (2014) In: (eds.), , 2739-2743. Wiley-IEEE Press. doi:10.1109/ECC.2014.6862188 Research article in edited proceedings (conference) \| Peer reviewed \| Published
Cross-Gramian Based Combined State and Parameter Reduction for Large-Scale Control Systems Himpe C, Ohlberger M (2014) In: Mathematical Problems in Engineering, 2014, 1-13. doi:10.1155/2014/843869 Research article (journal) \| Peer reviewed \| Published
A Unified Software Framework for Empirical Gramians Himpe C, Ohlberger M (2013) In: ((Bitte Journal prüfen)), 2013(2013), 1-6. doi:10.1155/2013/365909 Research article (journal) \| Peer reviewed \| Published