University of Münster
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CRC TRR 128 A08: Impact of dietary factors on the gut-CNS-axis-implications for CNS autoimmunity

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 31/12/2020 | 2nd Funding period

Description

Our project deals with the impact of specific dietary modifications on CNS autoimmunity, with a special focus on the link between bioactive nutrients, the gut microbiome, modulation of intestinal immune responses and the consequences for CNS autoimmunity. Part 1 deals with protective effects via dietary supplementation of conjugated linoleic acid. Part 2 investigates protective effects of a wheat/ATI-free diet. In part 3, we will perform first proof-of-concept studies in RRMS patients to evaluate the immune-modulatory effects of dietary CLA supplementation and a wheat/ATI-free diet in addition to standard treatment.

Keywords: gut-CNS-axis; CLA; MS; dietary factors
Website of the project: http://www.sfbtr128.de/projects/project-area-a-2/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/223524731
Funding identifier: TRR 128/2 | DFG project number: 213904703
Funder / funding scheme: 
  • DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Klotz, Luisa Hildegard
Department for Neurology

Applicants from the University of Münster

Klotz, Luisa Hildegard
Department for Neurology

Project partners outside the University of Münster

  • LMU KlinikumGermany
  • Max-Planck-Institute for Human Cognitive and Brain SciencesGermany
  • Technical University of Munich (TUM)Germany
  • Goethe University Frankfurt am MainGermany
  • Johannes Gutenberg University Mainz (JGU)Germany

Projects of the previous funding period

CRC TRR 128 A08 - The nuclear receptors liver X receptor (LXR) and farnesoid X receptor (FXR) - bridging adaptive and innate immune-regulatory responses in…
Duration: 01/07/2012 - 30/06/2016 | 1st Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted outside University of Münster

Projects of the following funding period

CRC TRR 128 - A08: Impact of diet and intestinal microbiota on the gut-CNS-axis – implications for CNS autoimmunity
Duration: 01/01/2021 - 30/06/2024 | 3rd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

SFB TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
Duration: 01/07/2016 - 31/12/2020 | 2nd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Main DFG-project hosted at University of Münster