CRC TRR 128 - A08: Impact of diet and intestinal microbiota on the gut-CNS-axis – implications for CNS autoimmunity
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period
Description
Our project deals with the mechanisms of gut-mediated modulation of autoimmune CNS responses. We observed that intestinal myeloid cells serve as "gatekeepers" of the intestinal immune system that react to defined dietary signals, thereby modulating systemic immune reactions and CNS autoimmunity. For a an improved modulation of intestinal myeloid cells we now focus on specific probiotic modulators in combination with a synergistic diet to identify the most promising formulation in preclinical MS models. This formulation will then be studied in a human interventional study aiming at therapeutic immune modulation in human MS patients.
Keywords: Multiple Sclerosis; gut-CNS-axis; CLA; MS; dietary factors
Website of the project: http://www.sfbtr128.de/a08/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/223524731
Funding identifier: TRR 128/4, A08 | DFG project number: 213904703
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Klotz, Luisa Hildegard |
Applicants from the University of Münster
| Klotz, Luisa Hildegard |
Project partners outside the University of Münster
- University Medical Center of the Johannes Gutenberg University MainzGermany
Projects of the previous funding period
Duration: 01/07/2016 - 31/12/2020 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2021 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |