CRC TRR 128 A08: Impact of diet and intestinal microbiota on the gut-CNS-axis – implications for CNS autoimmunity

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period

Description

Our project deals with the mechanisms of gut-mediated modulation of autoimmune CNS responses. We observed that intestinal myeloid cells serve as "gatekeepers" of the intestinal immune system that react to defined dietary signals, thereby modulating systemic immune reactions and CNS autoimmunity. For a an improved modulation of intestinal myeloid cells we now focus on specific probiotic modulators in combination with a synergistic diet to identify the most promising formulation in preclinical MS models. This formulation will then be studied in a human interventional study aiming at therapeutic immune modulation in human MS patients.

Keywords: Multiple Sclerosis; gut-CNS-axis; CLA; MS; dietary factors

Website of the project: http://www.sfbtr128.de/a08/

Funding identifier: TRR 128/4, A08

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Klotz, Luisa Hildegard

Department for Neurology

Applicants from the University of Münster