IRTG 1549 - Molecular and Cellular Glyco-Sciences (MCGS). Understanding Structure/Function Relationships of Carbohydrate/Protein-Interactions (MCGS)
Basic data for this project
Description
Carbohydrate-containing biomolecules are increasingly recognized as information-bearing molecules with highly important signaling and regulatory functions within and between cells and organisms. Many of these are due to direct interactions of the respective carbohydrates with cellular proteins, such as receptors or enzymes. Molecular and biochemical aspects of such carbohydrate/protein-interactions in the cellular context are being characterized in detail by our Indo-German International Research Training Group on MOLECULAR AND CELLULAR GLYCO-SCIENCES (MCGS). The focus is on structure/function-relationships, i.e. on elucidating the structural requirements responsible for the interaction of glycans with their target proteins. The German groups are focusing on the analytical and functional aspects of the carbohydrate moieties (e.g. identifying potential protein binding domains of glycans), while the Indian groups are mainly dealing with the protein aspects (e.g. identifying potential carbohydrate binding sites of specific agglutinins). Each doctoral project is jointly investigated by an Indian and a German group. This creates a basic understanding of structure/function-relationships at a molecular level and, thus, will allow us to eventually develop, validate, and apply the tools needed to exploit the biotechnological potential of glyco-structures for novel knowledge-driven applications.MCGS convenes a group of internationally recognized research teams from biology, chemistry, and medicine, initiating an interdisciplinary and intercultural approach for the doctoral candidates' training and education. MCGS accepts candidates with different degrees such as Bachelor, Master, Diplom, or federal exam, in different disciplines of natural and life sciences, including applied sciences such as biotechnology, pharmacy, medicine, pharmacology, agriculture, veterinary, food, and material sciences, from a competitive pool of international applicants. The MCGS study programm offers a basic Lecture cum Seminar on glyco-sciences, and three-weeks Summer and Winter Schools followed by one week Excursions, individual Technical Workshops and a range of Enabling Skills Workshops. MCGS organises bi-annual MCGS Network Symposia. MCGS comprises ca. 40 doctoral candidates and post-doctoral researchers advised by ca. 20 scientists, with half of the candidates and scientists from Germany, half from India.
- DFG - International Research Training Group (IGRK)
Project management at the University of Münster
| Deters, Alexandra | |
| Götte, Martin | |
| Goycoolea, Francisco M. | |
| Grobe, Kay | |
| Hensel, Andreas | |
| Hippler, Michael | |
| Moerschbacher, Bruno | |
| Mormann, Michael | |
| Müthing, Johannes |
Speakers from the University of Münster
| Moerschbacher, Bruno |
Applicants from the University of Münster
| Moerschbacher, Bruno |
Project partners outside the University of Münster
- University of Hyderabad (UH)India
Publications of the University of Münster resulting from the project
Kaiser M., Pohl L., Ketelhut S., Kastl L., Gorzelanny C., Götte M., Schnekenburger J., Goycoolea F., Kemper B. (2017) In: PloS one, 12(11). doi:10.1371/journal.pone.0187497 Research article (journal) | Peer reviewed | Published | |
Santos-Carballal B., Aaldering L., Ritzefeld M., Pereira S., Sewald N., Moerschbacher B., Götte M., Goycoolea F. (2015) In: Scientific Reports, 5. doi:10.1038/srep13567 Research article (journal) | Peer reviewed | Published | |
Fuenzalida J., Nareddy P., Moreno-Villoslada I., Moerschbacher B., Swamy M., Pan S., Ostermeier M., Goycoolea F. (2014) In: Food Hydrocolloids, null(null). doi:10.1016/j.foodhyd.2015.04.017 Research article (journal) | Peer reviewed | online first | |
Kaiser M., Pereira S., Pohl L., Ketelhut S., Kemper B., Gorzelanny C., Galla H., Moerschbacher B., Goycoolea F. (2015) In: Scientific Reports, 5(null). doi:10.1038/srep10048 Research article (journal) | Peer reviewed | Published | |
Madhuprakash Jogi, El Gueddari Nour Eddine, Moerschbacher Bruno M., Podile Appa Rao (2015) In: PloS one, 10(1). doi:10.1371/journal.pone.0116823 Research article (journal) | Peer reviewed | Published |
Doctorates resulting from the project
| The role of heparan sulfate 3-O- and 2-O-sulfation in breast cancer pathogenesis Candidate: Vijaya Kumar, Archana | Supervisors: Götte, Martin; Moerschbacher, Bruno Period of time: 01/04/2011 - 01/07/2014 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster | |
| Syndecan-1 and heparanase as novel regulators of colon cancer stem cell function Candidate: Kumar Katakam, Sampath | Supervisors: Götte, Martin; Moerschbacher, Bruno; Greve, Burkhard Period of time: 01/09/2011 - 01/04/2015 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster |
Distinctions resulting from the project
| Outstanding Achievement Award - Role of the Sulfotransferase HS3ST2 in breast cancer metastasis Awarded by: Spandidos Publishers - 16 th World Congress on Advances in Oncology Award given to: Götte, Martin Date of awarding: 15/10/2011 Type of distinction: Best publication award |
Talks about the project
| Role of Heparan Sulfate in Tumor-Initiating cells Götte; Martin (18/09/2015) 23rd Symposium on Glycosaminoglycans. Heparin centenary. Past, present and future perspectives , Villa Vigoni, Menaggio, Italien Type of talk: scientific Talk | |
| Interplay of Syndecan-1 and Heparanase in Cancer Stem Cell Function Götte, Martin (23/08/2015) 9th International Conference on Proteoglycans and 10th Pan-Pacific Connective Tissue Societies Symposium, Seoul, Korea Type of talk: scientific Talk | |
| HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4-dependent regulation of protease and cadherin expression. Martin Götte (11/11/2013) Novel Insights into Cancer Biology: New Targets and Therapeutic Approaches, Kairo, Ägypten Type of talk: scientific Talk |