CRC 629 A13 - Regulation of actin dynamics-driven processes during Drosophila development
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 05/06/2007 - 30/06/2015 | 2nd Funding period
Description
Developmental processes involving movement and cell shape changes are based on a highly dynamic reorganization of the actin cytoskeleton. Actin polymerization is controlled by members of WASP protein family, WASP, N-WASP and WAVE that activate the Arp2/3 complex in different developmental processes. Recent biochemical work from a number of laboratories showed that a protein complex comprising Sra-1, Kette and Abi regulates WAVE function (SKA-complex). We have shown that the activation of Sra-1, Kette or Abi by membrane recruitment leads to a prominent activation of WASP but not of WAVE. To understand how WAVE and WASP are differentially activated, we have screened for additional regulatory factors.
Keywords: cell shape; cytoskeleton; actin; actin polymerization; biochemistry
Website of the project: http://sfb629.uni-muenster.de
Funding identifier: INST 211/401-2:4
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Bogdan, Sven | Professorship of Neuro- and Behavioral Biology (Prof. Klämbt) |
Applicants from the University of Münster
| Bogdan, Sven | Professorship of Neuro- and Behavioral Biology (Prof. Klämbt) |