SFB 629 A13 - Regulation der Aktin-Dynamik während der Drosophila Entwicklung

Grunddaten zu diesem Projekt

Beschreibung

Developmental processes involving movement and cell shape changes are based on a highly dynamic reorganization of the actin cytoskeleton. Actin polymerization is controlled by members of WASP protein family, WASP, N-WASP and WAVE that activate the Arp2/3 complex in different developmental processes. Recent biochemical work from a number of laboratories showed that a protein complex comprising Sra-1, Kette and Abi regulates WAVE function (SKA-complex). We have shown that the activation of Sra-1, Kette or Abi by membrane recruitment leads to a prominent activation of WASP but not of WAVE. To understand how WAVE and WASP are differentially activated, we have screened for additional regulatory factors.