CRC 656 C08 - Functional imaging of anti-vascular treatment strategies with soluble tissue factor (SFB 656 C08)

Basic data for this project

Description

The selective activation of blood coagulation in tumor vessels by using truncated, soluble derivatives of human tissue factor (tTF) is a promising strategy in cancer therapy. The C-terminal peptide extensions (NGR or RGD, respectively) of the tTF fusion proteins allow for the selective binding to cell surface receptors like CD13 or αvβ3 integrin, which are over-expressed in several tumor endothelial cells. We will focus on target validation, verification of the anti-vascular mechanisms and treatment refinement by functional imaging by using optical and magnetic resonance imaging.