CRC 656 C08 - Functional imaging of anti-vascular treatment strategies with soluble tissue factor (SFB 656 C08)
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2009 - 30/06/2013 | 1st Funding period
Description
The selective activation of blood coagulation in tumor vessels by using truncated, soluble derivatives of human tissue factor (tTF) is a promising strategy in cancer therapy. The C-terminal peptide extensions (NGR or RGD, respectively) of the tTF fusion proteins allow for the selective binding to cell surface receptors like CD13 or αvβ3 integrin, which are over-expressed in several tumor endothelial cells. We will focus on target validation, verification of the anti-vascular mechanisms and treatment refinement by functional imaging by using optical and magnetic resonance imaging.
Keywords: blood coagulation
Website of the project: http://www.uni-muenster.de/Sfbmobil/projekte/organfunktion/c8.html
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Bremer, Christoph | Clinic of Radiology |
| Mesters, Rolf Michael | Medical Clinic of Internal Medicine A (Hematology, Oncology, and Oneumology) (Med A) |
| Persigehl, Thorsten | Clinic of Radiology |
Applicants from the University of Münster
| Bremer, Christoph | Clinic of Radiology |
| Mesters, Rolf Michael | Medical Clinic of Internal Medicine A (Hematology, Oncology, and Oneumology) (Med A) |