CRC TRR 332 - C07: Role of S100A8/A9 dimers and tetramers in the regulation of neutrophil dynamics in chronic inflammation

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2022 - 30/06/2026 | 1st Funding period

Description

The aim of the present proposal is to understand how neutrophils are controlled to prevent un-wanted immune system activation. We hypothesize that S100A8/A9 with its two occurring quaternary structures dimer versus tetramer differentially modulate neutrophils, with tetramers keeping them in a silent but alert mode upon dimer activation, thereby locally confining neutrophil activity. A better understanding of these regulatory mechanisms and how they can be tuned will pave the way towards novel therapeutic interventions in chronic inflammatory neutrophil-driven diseases.

Keywords: Chronische Entzündung

Website of the project: https://www.medizin.uni-muenster.de/sfb-trr-332/forschung/project-area-c.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505462901

Funding identifier: TRR 332/1, C07 | DFG project number: 449437943

Funder / funding scheme: