SFB TRR 332 - C07: Rolle von S100A8/A9-Dimeren und -Tetrameren bei der Regulierung der Neutrophilendynamik bei chronischer Entzündung

Grunddaten zu diesem Projekt

Beschreibung

The aim of the present proposal is to understand how neutrophils are controlled to prevent un-wanted immune system activation. We hypothesize that S100A8/A9 with its two occurring quaternary structures dimer versus tetramer differentially modulate neutrophils, with tetramers keeping them in a silent but alert mode upon dimer activation, thereby locally confining neutrophil activity. A better understanding of these regulatory mechanisms and how they can be tuned will pave the way towards novel therapeutic interventions in chronic inflammatory neutrophil-driven diseases.