CRC TRR 332- A02: Neutrophil education in peripheral vascular beds

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2022 - 30/06/2026 | 1st Funding period

Description

The aim of the present proposal is to unravel the importance of the vascular periphery – over and above processes occurring in the bone marrow – as site of end-stage neutrophil maturation. Given tremendous proteomic and transcriptomic difference in mature bone marrow and circulating neutrophils, we hypothesize that neutrophils undergo final stages of maturation in the periphery. Successfully addressing these aims would provide an innovative paradigm to understanding neutrophil biology as it will establish peripheral vascular beds as a novel (possibly disease generating) component during neutrophil maturation.

Keywords: Neutrophile

Website of the project: https://www.medizin.uni-muenster.de/sfb-trr-332/forschung/project-area-a.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505373248

Funding identifier: SFB TRR 332, A02 | DFG project number: 449437943

Funder / funding scheme: