CRC 1348 - A09: Regulation and Execution of Vesicle Formation in WASH-mediated Endocytosis

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2022 - 31/12/2025 | 2nd Funding period

Description

Tetraspanin-enriched microdomains (TEM) act as platforms in the plasma membrane regulating various biological processes. Depending on the composition of TEM, tetraspanins modulate, stabilize, or prevent the activities of associated molecules. In this project, we will analyze the role of the dynamic composition of TEM for induction and execution of a novel endocytic mechanism used by human papillomaviruses (HPV) for infection. In particular, we are interested in the recruitment of cellular factors regulating membrane bending and scission. Likewise, we aim to address the impact of endocytosis on the virus-induced, TEM-mediated signaling outcome.

Keywords: Biology; cellular interfaces; imaging modalities

Website of the project: http://sfb1348.uni-muenster.de/projects/a/project-a09

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/394345406

Funding identifier: SFB 1348/2 A09 | DFG project number: 386797833

Funder / funding scheme: