CRC TRR 128 B07: Linking cholesterol metabolism in myeloid cells to remyelination in mice and humans

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period

Description

The aim of our study is to understand how different functional states of myeloid cells are linked to oligodendrocytes and remyelination in MS lesions. We will 1. dissect the molecular mechanisms underlying impaired remyelination caused by a maladaptive immune response induced by accumulated myelin debris in myeloid cells and 2. test the hypothesis that lipidated ApoE particles formed after myelin debris clearance are reutilized by oligodendrocytes to provide cholesterol for remyelination. To address our questions we will combine our expertise in oligodendroglial and myelin biology, neuropathology, stem cell technologies and molecular biology.

Keywords: Multiple sclerosis

Website of the project: http://www.sfbtr128.de/b07/

Funding identifier: TRR 128/4, B07

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Kuhlmann, Tanja

Institute of Neuropathology

Applicants from the University of Münster