CRC TRR 128 - B07: Linking cholesterol metabolism in myeloid cells to remyelination in mice and humans
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period
Description
The aim of our study is to understand how different functional states of myeloid cells are linked to oligodendrocytes and remyelination in MS lesions. We will 1. dissect the molecular mechanisms underlying impaired remyelination caused by a maladaptive immune response induced by accumulated myelin debris in myeloid cells and 2. test the hypothesis that lipidated ApoE particles formed after myelin debris clearance are reutilized by oligodendrocytes to provide cholesterol for remyelination. To address our questions we will combine our expertise in oligodendroglial and myelin biology, neuropathology, stem cell technologies and molecular biology.
Keywords: Multiple sclerosis
Website of the project: http://www.sfbtr128.de/b07/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/223898965
Funding identifier: TRR 128/4, B07 | DFG project number: 213904703
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Kuhlmann, Tanja |
Applicants from the University of Münster
| Kuhlmann, Tanja |
Project partners outside the University of Münster
- Technical University of Munich (TUM)Germany
Projects of the previous funding period
Duration: 01/07/2016 - 31/12/2020 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2021 - 30/06/2024 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |