Synthesis of spirocycles through C-H-activation and their application in medicinal chemistry

Basic data for this project

Type of projectIndividual project
Duration at the University of Münster01/01/2022 - 31/12/2023

Description

The aim of this project is to synthesize spirocyclic lactones and evaluate them as potential sigma receptor ligands. These target structures are characterized by a generally difficult to access three-dimensional structure. In this project, a novel synthetic method will be developed to build such structures. For this purpose, a palladium-catalyzed cleavage of usually unreactive carbon-hydrogen bonds (C-H activation) will be used to react with carboxylic acids in a regioselective manner. Via olefination and subsequent cyclization, the targeted structures will be built using nitrogen-containing carboxylic acids as reactants, which have not been used in the literature so far. The project includes the development and optimization of suitable catalysts and reaction conditions, as well as the subsequent establishment of a broad substance library for biochemical evaluation.

KeywordsPhysical Chemistry of Solids and Surfaces; Material Characterisation
Website of the projecthttps://gepris.dfg.de/gepris/projekt/490859623
DFG-Gepris-IDhttps://gepris.dfg.de/gepris/projekt/490859623
Funding identifierHI 2351/1-1 | DFG project number: 490859623
Funder / funding scheme
  • DFG - Walter Benjamin Programme

Project management at the University of Münster

Hiesinger, Kerstin
Independent Junior Research Group Dr. Manuel van Gemmeren
van Gemmeren, Manuel
Independent Junior Research Group Dr. Manuel van Gemmeren

Applicants from the University of Münster

Hiesinger, Kerstin
Independent Junior Research Group Dr. Manuel van Gemmeren