CRC 1009 - B08: DAMP-induced proinflammatory feedback mechanisms between phagocytes and endothelial / epithelial barriers in infectious diseases

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period

Description

The innate host defense system reacts quickly and adequately against invading pathogens. Thereby the immune response is supported by the release of the alarmin S100A8/A9 initiating a TLR4 dependent immune cell activation. Heterodimeric S100A8/A9 inactivates itself by calcium-dependent tetramer formation restricting the immune response locally. In the last funding period we will characterize the implications, if this regulatory mechanism cannot take place anymore in infectious mouse models and develop a nanobody/antibody based strategy to block or neutralize the activity of S100A8/A9 heterodimers.

Keywords: Immunology; Phagocyte biology; danger signalling

Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-08.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222662725

Funding identifier: SFB 1009/3, B08 | DFG project number: 194468054

Funder / funding scheme: