CRC 1009 - B03: Autopenetration of bacterial effector proteins and modulation of signalling responses in cellular barriers

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period

Description

Effector proteins can also enter host cells in a type III secretion system (T3SS)-independent manner thereby widening their potential functional range to modulate cellular barriers. In this regard, we identified the entire group of bacterial leucine-rich repeat (LPX) effector proteins as so far unknown cell-penetrating effector proteins (CPE), which provided further evidence for a general concept of T3SS-independent translocation. Now we will elucidate the effects of this novel class of CPE in modulating immune responses in cell-culture and animal models and explore potential therapeutic applications of these CPE.

Keywords: Medical Microbiology; Mycology; Hygiene; Molecular Infection Biology

Website of the project: https://www.medizin.uni-muenster.de/en/sfb-1009/projects/project-area-b/b-03.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222660978

Funding identifier: SFB 1009/3, B03 | DFG project number: 194468054

Funder / funding scheme: