EXC 1003 FF-2016-15 - Quantitative analysis of local subcellular cell junction activity by JAIL formation and its impact on endothelial cell migration and barrier function

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/08/2016 - 30/06/2018 | 1st Funding period

Description

Researchers from Münster have recently discovered: Special cell protuberances, so-called junction associated intermittent lamellipodia (JAIL), decide how firmly endothelial cells are joined together. Endothelial cells lines the interior of blood vessels. Circular, flat cell protuberances (lamellipodia) are formed which overlap other cells. Researchers assume that JAIL are important not only for healing processes in wounds, but also in the case of inflammations or vascular development. However, many details are still unclear. For example, how many JAIL are needed to close gaps between cells? Are just a few, at appropriate places, sufficient? When and where are JAIL formed? How large should they be?

Keywords: image processing; mathematical biology

Website of the project: https://www.uni-muenster.de/Cells-in-Motion/de/research/projects/flexible-funds/FF-2016-15.php

Funding identifier: FF-2016-15

Funder / funding scheme: