University of Münster
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CRC TRR 128 B03: Molecular mechanisms and in vivo tracking of leukocyte penetration of the blood-brain barrier (BBB) in autoimmune CNS inflammation

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 31/12/2020 | 2nd Funding period

Description

B03 developed and employed specific probes for molecular imaging to show that imaging of MMP-2/-9 activity in EAE and human MS is a reliable marker of leukocyte infiltration into the CNS parenchyma. We will elucidate how MMPs are regulated at the BBB and correlate MMP activity with infiltration of specific T cell subsets using novel imaging-based cell-tracking approaches. This will provide unique non-invasive tools to learn more about lesion development and lesion resolution and will finally permit molecular imaging of extreme MS phenotypes and.

Keywords: Molekulare und Zelluläre Neurologie; Neuropathologie
Website of the project: http://www.sfbtr128.de/
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/223527446
Funding identifier: TRR 128/2 | DFG project number: 213904703
Funder / funding scheme: 
  • DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Schäfers, Michael
European Institute for Molecular Imaging (EIMI)
Sorokin, Lydia
Institute of Physiological Chemistry and Pathobiochemistry

Applicants from the University of Münster

Schäfers, Michael
European Institute for Molecular Imaging (EIMI)
Sorokin, Lydia
Institute of Physiological Chemistry and Pathobiochemistry

Projects of the previous funding period

SFB TRR 128 B03 - MMP-2 and MMP-9 in penetration of the CNS parenchymal in murine EAE; functional analyses and molecular in vivo imaging
Duration: 01/07/2012 - 30/06/2016 | 1st Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted outside University of Münster

Projects of the following funding period

CRC TRR 128 - B03: Molecular mechanisms and sites of action of the gelatinases in autoimmune CNS inflammation: do MMP-2/-9 contribute to meningeal inflammation…
Duration: 01/01/2021 - 30/06/2024 | 3rd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

SFB TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
Duration: 01/07/2016 - 31/12/2020 | 2nd Funding period
Funded by: DFG - Collaborative Research Centre
Type of project: Main DFG-project hosted at University of Münster