CRC TRR 128 B03: Molecular mechanisms and in vivo tracking of leukocyte penetration of the blood-brain barrier (BBB) in autoimmune CNS inflammation
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 31/12/2020 | 2nd Funding period
Description
B03 developed and employed specific probes for molecular imaging to show that imaging of MMP-2/-9 activity in EAE and human MS is a reliable marker of leukocyte infiltration into the CNS parenchyma. We will elucidate how MMPs are regulated at the BBB and correlate MMP activity with infiltration of specific T cell subsets using novel imaging-based cell-tracking approaches. This will provide unique non-invasive tools to learn more about lesion development and lesion resolution and will finally permit molecular imaging of extreme MS phenotypes and.
Keywords: Molekulare und Zelluläre Neurologie; Neuropathologie
Website of the project: http://www.sfbtr128.de/
Funding identifier: TRR 128/2
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Schäfers, Michael | European Institute of Molecular Imaging (EIMI) |
| Sorokin, Lydia | Institute of Physiological Chemistry and Pathobiochemistry |
Applicants from the University of Münster
| Schäfers, Michael | European Institute of Molecular Imaging (EIMI) |
| Sorokin, Lydia | Institute of Physiological Chemistry and Pathobiochemistry |