CRC TRR 128 B03: Molecular mechanisms and sites of action of the gelatinases in autoimmune CNS inflammation: do MMP-2/-9 contribute to meningeal inflammation and secondary cortical damage?
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period
Description
Meningeal inflammation results in cortical damage and correlates with disability in MS, but is poorly understood. We showed that gelatinases (matrix metalloproteinase (MMP)-2 and -9) control leukocyte penetration of the blood-brain barrier at postcapillary venules and propose that they serve similar functions at the meningeal-brain border. We will investigate gelatinases in the meninges of MS patients and mouse EAE, identify novel gelatinase substrates that induce meningeal inflammation, and test these substrates in patients. Meningeal T cells will be tracked in mice lacking MMP-2/-9. By understanding meningeal inflammation, we aim to understand drivers of disability in MS.
Keywords: Multiple sclerosis
Website of the project: http://www.sfbtr128.de/b03/
Funding identifier: TRR 128/4, B03
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Meyer zu Hörste, Gerd Heinrich Rudolf | Department for Neurology |
| Sorokin, Lydia | Institute of Physiological Chemistry and Pathobiochemistry |
Applicants from the University of Münster
| Meyer zu Hörste, Gerd Heinrich Rudolf | Department for Neurology |
| Sorokin, Lydia | Institute of Physiological Chemistry and Pathobiochemistry |