SFB128 Project B01: Immune regulation at the CNS barriers and in the CNS: role of immune cell trafficking
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2016 - 31/12/2020 | 2nd Funding period
Description
Blocking of adhesion molecules can reduce MS activity, but VLA-4 is not equally relevant for all immune cells; TH17 cells can enter the CNS without it, namely via MCAM expression. The MCAM phenotype will be analyzed, as well as its role in transmigration into the CNS, in immune surveillance under (non)inflammatory conditions, and its potential usage of integrin VLA-2, which is preferentially expressed by these cells. We will combine human and murine experiments using conventional approaches (kinase inhibitors, transgenic mice, EAE), but also state-of-the-art spinning-disc microscopy to visualize MCAM-mediated CNS infiltration in vivo.
Keywords: Neuroimmunologie; Multiple Sklerose
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/223525770
Funding identifier: TRR 128/2 | DFG project number: 213904703
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Schwab, Nicholas Christopher | Department for Neurology |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
Applicants from the University of Münster
| Schwab, Nicholas Christopher | Department for Neurology |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |