CRC TRR 128 B01: Immune regulation at the CNS barriers and in the CNS: role of immune cell trafficking
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 30/06/2024 | 3rd Funding period
Description
Infiltration of immune cells into the CNS is one major hallmark of MS pathology. After elucidating immune signatures for different routes into the CNS in the first two funding periods, we will 1) investigate the relationship between therapeutic integrin engagement and selectin expression for lymphocyte surveillance function with implications for virus control, 2) analyze the antigen specificity of MCAM+ and CCR5high CNS-infiltrating T cells to decipher their exact roles in CNS immune surveillance versus inflammation, and 3) transfer the generated molecular and cellular concepts of adaptive CNS immunity to the coagulation system and analyze the contribution of leukocyte-platelet aggregates to adaptive CNS immunity in the context of MS.
Keywords: Multiple sclerosis
Website of the project: http://www.sfbtr128.de/b01/
Funding identifier: TRR 128/4, B01
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Schwab, Nicholas Christopher | Department for Neurology |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |
Applicants from the University of Münster
| Schwab, Nicholas Christopher | Department for Neurology |
| Zarbock, Alexander | Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy |