EXC 1003 FF-2016-11 - Effects of newly generated, peripherally-selective, anti-inflammatory kappa-opioid receptor agonists in the treatment of progressive CNS inflammation and neurodegeneration

Basic data for this project

Description

Multiple Sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system (CNS). Is a therapy, which is restricted to the periphery (i.e. to sites where pathogenic effector cells are developing), sufficient to down-regulate inflammation in the CNS? Which role might agonists of the κ(kappa) opioid receptor, a subtype of opioid receptors, play in this scenario? These are questions, which will be addressed by researchers from different disciplines in this CiM project.