CRC TRR 332 - A03: Regulation of neutrophils through thrombospondin- 1 in chronic urinary tract infection (cUTI)
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2026 - 30/06/2030 | 2nd Funding period
Description
Chronic urinary tract infections (cUTI) cause persistent neutrophil recruitment, tissue damage, and kidney fibrosis. Neutrophils clear bacteria but also exacerbate injury, promoting fibrosis. Thrombospondin- 1 (TSP1), a multifunctional extracellular matrix glycoprotein, interacts with neutrophils via MMP2, MMP9, and elastase, and regulates active TGF-β1 release, influencing neutrophil polarization and fibrotic processes. Thus, TSP1 may be a key environmental factor regulating neutrophil and fibrosis. Using experimental models, human samples, and advanced technologies, we investigate TSP1's role in neutrophil polarization, tissue microenvironment interactions, and renal fibrosis in cUTI.
Keywords: urinary tract infection; infammation; Neutrophils; bacteria
Website of the project: https://neutrophils.de/en/project/22
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/505373873
Funding identifier: TRR 332/2, A03 | DFG project number: 449437943
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project partners outside the University of Münster
- University of Duisburg-Essen (UDE)Germany
Related main project
CRC TRR 332: Neutrophils: origin, fate & function (SFB TRR 332) Duration: 01/07/2026 - 30/06/2030 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |