SFB TRR 332 - A03: Regulation von Neutrophilen durch Thrombospondin-1 bei chronischen Harnwegsinfektionen (cUTI)

Grunddaten zu diesem Projekt

Beschreibung

Chronic urinary tract infections (cUTI) cause persistent neutrophil recruitment, tissue damage, and kidney fibrosis. Neutrophils clear bacteria but also exacerbate injury, promoting fibrosis. Thrombospondin- 1 (TSP1), a multifunctional extracellular matrix glycoprotein, interacts with neutrophils via MMP2, MMP9, and elastase, and regulates active TGF-β1 release, influencing neutrophil polarization and fibrotic processes. Thus, TSP1 may be a key environmental factor regulating neutrophil and fibrosis. Using experimental models, human samples, and advanced technologies, we investigate TSP1's role in neutrophil polarization, tissue microenvironment interactions, and renal fibrosis in cUTI.