CRC 1348 - A09: Regulation and Execution of Vesicle Formation in WASH-mediated Endocytosis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 3rd Funding period
Description
Viruses exploit existing cellular mechanisms for transport across dynamic cellular interfaces. During cell invasion, human papillomaviruses (HPV) use a unique clathrin-independent endocytic pathway that we term WASH-mediated endocytosis (WASH-ME). Here, we will analyze how phosphoinositides and BAR-domain-containing proteins contribute to vesicle formation at the plasma membrane, and how the extracellular matrix constituent laminin-332 regulates the intracellular cargo destination of WASH-ME by following HPV as a model cargo.
Keywords: Biologie; zelluläre Kontaktstellen; Bildgebung
Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_A09.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/394345406
Funding identifier: SFB 1348/3, A09 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Schelhaas, Mario | Institute of Cellular Virology |
Applicants from the University of Münster
| Schelhaas, Mario | Institute of Cellular Virology |