CRC 1748 - A06: Characterisation of the zygotene cilium in human spermatogenesis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period
Description
Azoospermia, i.e., the lack of sperm in the ejaculate, is often caused by sperm production arrested at meiosis. Studies in zebrafish and mice indicate that meiosis is regulated by a non-motile primary cilium emanating from zygotene spermatocytes. This suggests that ciliopathies, so far rather known to affect sperm motility, may also impact meiosis and spermatogenesis. This project will investigate the role of primary cilia and associated genes and proteins in the human testis, unravelling whether dysfunction of primary cilia represents an as yet unrecognised pathomechanism of human male infertility.
Keywords: Azoospermie
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/574757409
Funding identifier: SFB 1748, A06 | DFG project number: 549467913
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Friedrich, Corinna | Institute of Reproductive Genetics |
| Wallmeier, Julia | Institute of Human Genetics |
Applicants from the University of Münster
| Friedrich, Corinna | Institute of Reproductive Genetics |
| Wallmeier, Julia | Institute of Human Genetics |