CRC 1748 - A03: Functional genetics in male congenital malformations
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period
Description
The risk for infertility and testicular cancer is significantly increased in males with faulty testicular decent (termed cryptorchidism), which is controlled by testosterone released by testicular Leydig cells. To unravel the mechanisms underlying this common male congenital malformation, this project combines clinical and genetic data. Functional genomics will be applied to assess the impact of candidate genes and testosterone level-associated variants identified in affected patients. In vitro screening approaches will be used to test the function of candidate genes in Leydig cells. This will improve diagnostics and targeted interventions for affected individuals.
Keywords: funktionelle Genomik; Hodenhochstand
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/574755712
Funding identifier: SFB 1748/1, A03 | DFG project number: 549467913
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Busch, Alexander | University Children's Hospital - Department for General Paediatrics |
| Ziller, Michael Johannes | Clinic for Mental Health |
Applicants from the University of Münster
| Busch, Alexander | University Children's Hospital - Department for General Paediatrics |
| Ziller, Michael Johannes | Clinic for Mental Health |