CRC TRR 422 - C03: Genetically enhanced podocytes to uncover mechanisms of podocyte resilience

Basic data for this project

Type of project: Subproject in DFG-joint project hosted outside University of Münster

Duration at the University of Münster: 01/10/2025 - 30/06/2029 | 1st Funding period

Description

Enhancing podocyte resilience while preserving their postmitotic nature represents a viable approach to combat glomerular diseases. Therefore, we will investigate genetic programs underlying podocyte resilience to disease-relevant stressors. Specifically, we will map transcriptional landscapes of podocyte models to identify pathways linked to survival or damage, characterize injury-induced responses in organoid-based kidney disease models pinpointing resilience-associated pathways, and validate candidate mediators by genetic and pharmacologic interventions.

Keywords: Nephrology; Cell Biology

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/566122767

Funding identifier: TRR 422/1, C03 | DFG project number: 543604419

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Döser, Markus Carl	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)
Pavenstädt, Hermann-Joseph	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)

Applicants from the University of Münster

Döser, Markus Carl	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)
Pavenstädt, Hermann-Joseph	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)

Coordinating organisations outside the University of Münster

University Hospital CologneGermany

Related main project

CRC TRR 422: Podocyte Signaling Networks - From Basic Concepts to Disease Understanding (PodoSigN)

Duration: 01/10/2025 - 30/06/2029

Funded by: DFG - Collaborative Research Centre

Type of project: Main DFG-project hosted outside University of Münster