CRC TRR 422 - C03: Genetically enhanced podocytes to uncover mechanisms of podocyte resilience
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/10/2025 - 30/06/2029 | 1st Funding period
Description
Enhancing podocyte resilience while preserving their postmitotic nature represents a viable approach to combat glomerular diseases. Therefore, we will investigate genetic programs underlying podocyte resilience to disease-relevant stressors. Specifically, we will map transcriptional landscapes of podocyte models to identify pathways linked to survival or damage, characterize injury-induced responses in organoid-based kidney disease models pinpointing resilience-associated pathways, and validate candidate mediators by genetic and pharmacologic interventions.
Keywords: Nephrology; Cell Biology
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/566122767
Funding identifier: TRR 422/1, C03 | DFG project number: 543604419
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Döser, Markus Carl | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Pavenstädt, Hermann-Joseph | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Applicants from the University of Münster
| Döser, Markus Carl | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Pavenstädt, Hermann-Joseph | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Coordinating organisations outside the University of Münster
- University Hospital CologneGermany