CRC TRR 422 - C02: Disruption of nuclear pores in podocyte injury
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/10/2025 - 30/06/2029 | 1st Funding period
Description
Mutations in genes that encode nucleoporins (NUPs), structural components of nuclear pores, cause FSGS. This project investigates the role of NUPs in maintaining podocyte homeostasis. We hypothesize that intact nuclear pores are essential for preserving podocyte-specific gene expression, while mutations in NUPs alter transcriptional programs and increase susceptibility to injury. Here, we will characterize transcriptomic changes caused by NUP mutations, assess how these mutations affect podocyte resilience, uncover mechanisms by which NUP mutations disrupt transcriptional regulation, and explore non-canonical NUP functions.
Keywords: Nephrology; Cell Biology
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/566120433
Funding identifier: TRR 422/1, C02 | DFG project number: 543604419
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Braun, Daniela Anne | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Menke, Amelie Friederike | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Applicants from the University of Münster
| Braun, Daniela Anne | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Menke, Amelie Friederike | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Coordinating organisations outside the University of Münster
- University Hospital CologneGermany