CRC TRR 422 - C02: Disruption of nuclear pores in podocyte injury

Basic data for this project

Type of project: Subproject in DFG-joint project hosted outside University of Münster

Duration at the University of Münster: 01/10/2025 - 30/06/2029 | 1st Funding period

Description

Mutations in genes that encode nucleoporins (NUPs), structural components of nuclear pores, cause FSGS. This project investigates the role of NUPs in maintaining podocyte homeostasis. We hypothesize that intact nuclear pores are essential for preserving podocyte-specific gene expression, while mutations in NUPs alter transcriptional programs and increase susceptibility to injury. Here, we will characterize transcriptomic changes caused by NUP mutations, assess how these mutations affect podocyte resilience, uncover mechanisms by which NUP mutations disrupt transcriptional regulation, and explore non-canonical NUP functions.

Keywords: Nephrology; Cell Biology

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/566120433

Funding identifier: TRR 422/1, C02 | DFG project number: 543604419

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Braun, Daniela Anne	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)
Menke, Amelie Friederike	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)

Applicants from the University of Münster

Braun, Daniela Anne	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)
Menke, Amelie Friederike	Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D)

Coordinating organisations outside the University of Münster

University Hospital CologneGermany

Related main project

CRC TRR 422: Podocyte Signaling Networks - From Basic Concepts to Disease Understanding (PodoSigN)

Duration: 01/10/2025 - 30/06/2029

Funded by: DFG - Collaborative Research Centre

Type of project: Main DFG-project hosted outside University of Münster