CRC TRR 422 - C01: The Ajuba/YAP/TAZ module interconnects cytoskeletal dynamics signaling and transcriptional programs to maintain podocyte homeostasis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/10/2025 - 30/06/2029 | 1st Funding period
Description
YAP/TAZ, key regulators in the Hippo signaling pathway, and Ajuba proteins, modulators of cytoskeletal and cell junction dynamics, play crucial roles in mechanotransduction. This project focuses on their role in maintaining podocyte health by translating mechanical extracellular signals into precise transcriptional responses. We aim to investigate how Ajuba proteins mediate signaling from the slit diaphragm to modulate YAP/TAZ networks, characterize mechanisms of Ajuba/YAP/TAZ nuclear activity, including liquid-liquid phase separation, and study the impact of Ajuba/YAP/TAZ deregulation during injury.
Keywords: Nephrology; Cell Biology
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/566108349
Funding identifier: TRR 422/1, C01 | DFG project number: 543604419
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Vollenbröker, Beate | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Applicants from the University of Münster
| Vollenbröker, Beate | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Project partners outside the University of Münster
- University Hospital CologneGermany
Coordinating organisations outside the University of Münster
- University Hospital CologneGermany