CRC TRR 422 - B01: Calcium-regulated actin organization in podocyte dysfunction and injury
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/10/2025 - 30/06/2029 | 1st Funding period
Description
The interplay between intracellular calcium and actin dynamics is a key factor in podocyte biology. Consequently, defects in calcium regulation and actin organization, like mutations in INF2, lead to focal segmental glomerulosclerosis (FSGS). Here, we will study the mechanisms of Ca2+-mediated actin rearrangements and plasma membrane repair in podocytes using cell-based and in vivo experiments with a focus on the role of INF2 in plasma membrane (PM) repair, the interplay between the actin cytoskeleton, calcium, and INF2 and the consequences of constitutive INF2 activity for podocyte homeostasis.
Keywords: Nephrology; Cell Biology
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/566095757
Funding identifier: TRR 422/1, B01 | DFG project number: 543604419
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Wedlich-Söldner, Roland | Institute for Cell Dynamics and Imaging |
Applicants from the University of Münster
| Wedlich-Söldner, Roland | Institute for Cell Dynamics and Imaging |
Project partners outside the University of Münster
- University Hospital CologneGermany
Coordinating organisations outside the University of Münster
- University Hospital CologneGermany