CRC TRR 422 - A03: Podocyte polarity signaling: The role of the Crumbs2 complex in podocyte maturation and maintenance
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/10/2025 - 30/06/2029 | 1st Funding period
Description
The project aims to uncover Crb2’s role in podocyte structural organization and to distinguish its functions at the in slit diaphragm (SD) from polarity signaling. Using mouse models, 2D/3D cultures, and organoids (Crb2 knockout and GFP-tagged systems), snRNA-sequencing, and super-resolution imaging, we will investigate Crb2’s mechanisms, functions, and dynamics during podocyte maturation, differentiation, and in disease. Key aspects include investigations of details concerning Crb2 localization and turnover, interaction partners at the SD, signaling networks, and the role of polarity signaling in podocyte maturation and maintenance.
Keywords: Nephrology; Cell Biology
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/565968998
Funding identifier: TRR 422/1, A03 | DFG project number: 543604419
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Möller-Kerutt, Annika | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Weide, Thomas | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Applicants from the University of Münster
| Möller-Kerutt, Annika | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
| Weide, Thomas | Medical Clinic of Internal Medicine D (Nephrology and Rheumatology) (Med D) |
Coordinating organisations outside the University of Münster
- University Hospital CologneGermany