CRC 1450 - C05: The role of CSK in the regulation of immune cell recruitment and metabolism during acute kidney injury

Basic data for this project

Type of projectSubproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster01/01/2025 - 31/12/2028 | 2nd Funding period

Description

Acute kidney injury (AKI) is characterised by impaired perfusion, a metabolic shift towards anaerobic glucose consumption and the secretion of pro-inflammatory mediators. We hypothesize that interleukin 24, which we recently identified in kidneys with AKI, is a key mediator in AKI. This leads us to investigate the influence of interleukin 24 on the functional, metabolic and cellular response of kidney cells and leukocytes during all stages of AKI. We will use a multiscale imaging approach with special emphasis on the development and application of novel magnetic resonance imaging (MRI) techniques, such as Chemical Exchange Saturation Transfer (CEST) MRI.

Keywords C-terminale Src-Kinase; Nierenversagen; Interleukin 24
Website of the projecthttps://www.uni-muenster.de/CRC-inSight/research/area-C/C05.php
DFG-Gepris-IDhttps://gepris.dfg.de/gepris/projekt/452345774
Funding identifierSFB 1450/2, C05
Funder / funding scheme
  • DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Hörr, Verena
Clinic of Radiology
Margraf, Andreas
Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy

Applicants from the University of Münster

Hörr, Verena
Clinic of Radiology
Margraf, Andreas
Clinic for Anaesthesiology, Surgical Critical Care Medicine and Pain Therapy

Research associates from the University of Münster

Schache, Daniel
Clinic of Radiology