CRC 1450 - C01: Metabolic priming of monocytes during inflammation in vivo
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2025 - 31/12/2028 | 2nd Funding period
Description
Monocytes represent a heterogeneous population, which, depending on their stage of differentiation and activation, either can promote inflammation or induce resolution and repair. Time and duration of initial exogenous or endogenous triggers may determine such subsequent pro- or anti-inflammatory monocyte response patterns partially through shifts between glucose and lipid metabolism (metabolic priming). We aim at monitoring metabolism and spatio-temporal dynamics of monocytes and their functional contribution to inflammation through tracking of monocytes and dynamic metabolic imaging in murine models of autoimmunity-, hypoxia- and infection-driven inflammation.
Keywords: Monozyten; Entzündung
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-C/C01.php
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452340249
Funding identifier: SFB 1450/2, C01 | DFG project number: 431460824
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Roth, Johannes | |
| Schäfers, Michael |
Applicants from the University of Münster
| Roth, Johannes | |
| Schäfers, Michael |
Research associates from the University of Münster
| Dabel, Jennifer | |
| Heiden, Nadine Christine | |
| Jansen, Lea | |
| Mittrowann, Ricarda |
Projects of the previous funding period
Duration: 01/01/2021 - 31/12/2024 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2025 - 31/12/2028 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |