CRC 1450 - A03: Targeting of S100A8/A9 for imaging of inflammatory disorders
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2025 - 31/12/2028 | 2nd Funding period
Description
Activated monocytes and granulocytes are key to inflammatory diseases and release the alarmin S100A8/A9 in high concentrations, promoting sterile as well as infectious inflammatory processes via TLR4 (1). We will establish a specific S100A8/A9 small molecule ligand through combination of X-ray structure analysis and chemical synthesis (2, 3). The ligand will be linked to different labels suited for PET, SPECT, fluorescent or photoacoustic imaging techniques (4). In summary, we will create a new S100 alarmin-based imaging toolset to monitor inflammatory responses with respect to their spatial location and temporal dynamics at various scales in living organisms.
Keywords: Monozyten; PET; Fluoreszenzanalyse; photoakustische Analyse
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-A/A03.php
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452337011
Funding identifier: SFB 1450/2, A03
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Faust, Andreas | European Institute of Molecular Imaging (EIMI) |
Applicants from the University of Münster
| Faust, Andreas | European Institute of Molecular Imaging (EIMI) |
Research associates from the University of Münster
| Dewies, Felix | European Institute of Molecular Imaging (EIMI) |
Project partners outside the University of Münster
- University of HohenheimGermany