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Dr. Susanne Ledig

Current affiliations

Institute of Human Genetics

Curriculum Vitae (CV)

moleculare factors of sexual development / disorders of sexual development
female infertility

Academic Education
01/2000 - 08/2003	Dissertation at Hanover Medical School
10/1993 - 12/1999	Studies in biology (Diplom) at the University of Hannover
Work Experience
since 10/2007	Postdoctoral research assistant at the Institute of Human Genetics of the University Hospital Münster
02/2004 - 09/2007	Postdoctoral research assistant at IHG, University of Magdeburg
Functions and Memberships
since 2005	Gesellschaft für Humangenetik

Publications

Genetic Architecture of Azoospermia-Time to Advance the Standard of Care. Wyrwoll, Margot J; Köckerling, Nils; Vockel, Matthias; Dicke, Ann-Kristin; Rotte, Nadja; Pohl, Eva; Emich, Jana; Wöste, Marius; Ruckert, Christian; Wabschke, Rebecca; Seggewiss, Jochen; Ledig, Susanne; Tewes, Ann-Christin; Stratis, Yvonne; Cremers, Jann-Frederik; Krallmann, Claudia; Wistuba, Joachim; Röpke, Albrecht; Kliesch, Sabine; Friedrich, Corinna; Stallmeyer, Birgit; Tüttelmann, Frank (2022) In: European Urology, 83(5), 452-462. doi:10.1016/j.eururo.2022.05.011 Research article (journal) \| Peer reviewed \| Published
Bi-allelic mutations in M1AP are a frequent cause of meiotic arrest and severely impaired spermatogenesis leading to male infertility. Wyrwoll, Margot J; Temel, Şehime G; Nagirnaja, Liina; Oud, Manon S; Lopes, Alexandra M; van der Heijden, Godfried W; Heald, James S; Rotte, Nadja; Wistuba, Joachim; Wöste, Marius; Ledig, Susanne; Krenz, Henrike; Smits, Roos M; Carvalho, Filipa; Gonçalves, João; Fietz, Daniela; Türkgenç, Burcu; Ergören, Mahmut C; Çetinkaya, Murat; Başar, Murad; Kahraman, Semra; McEleny, Kevin; Xavier, Miguel J; Turner, Helen; Pilatz, Adrian; Röpke, Albrecht; Dugas, Martin; Kliesch, Sabine; Neuhaus, Nina; GEMINI Consortium; Aston, Kenneth I; Conrad, Donald F; Veltman, Joris A; Friedrich, Corinna; Tüttelmann, Frank (2020) In: American Journal of Human Genetics, 107(2), 342-351. doi:10.1016/j.ajhg.2020.06.010 Research article (journal) \| Peer reviewed \| Published
Four novel NR5A1 mutations in 46,XY gonadal dysgenesis patients including frameshift mutations with altered subcellular SF-1 localization Rehkämper J., Tewes A., Horvath J., Scherer G., Wieacker P., Ledig S. (2018) In: Sexual Development, 11(null), 248-253. doi:10.1159/000484915 Research article (journal) \| Peer reviewed \| Published
New Territory for an Old Disease: 5-Alpha-Reductase Type 2 Deficiency in Bulgaria Andonova S., Robeva R., Vazharova R., Ledig S., Grozdanova L., Stefanova E., Bradinova I., Todorov T., Hadjidekov G., Sirakov M., Wieacker P., Kumanov P., Savov A. (2017) In: Sexual Development, 11(1), 21-28. doi:10.1159/000454974 Research article (journal) \| Peer reviewed \| Published
Recurrent aberrations identified by array-CGH in patients with Mayer-Rokitansky-Küster-Hauser syndrome. Ledig S, Schippert C, Strick R, Beckmann MW, Oppelt PG, Wieacker P (2011) In: Fertility and Sterility, 95(5), 1589-1594. Research article (journal) \| Published

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Projects

FOR 1041 Subproject - Molecular analysis of disorders of gonadal development Duration: 01/06/2011 - 30/06/2014 \| 2nd Funding period Funded by: DFG - Research Unit Type of project: Subproject in DFG-joint project hosted at University of Münster
Investigation of the molecular pathogenesis and pathophysiology of Disorders of Sex Development (DSD) (EuroDSD) Duration: 01/05/2008 - 31/10/2011 Funded by: EC FP 7 - Small or medium-scale focused research project Type of project: EU-project hosted outside University of Münster
FOR 1041 Subproject - Genetic analysis of Premature Ovarian Failure (POP) syndrome Duration: 01/05/2008 - 30/05/2011 \| 1st Funding period Funded by: DFG - Research Unit Type of project: Subproject in DFG-joint project hosted at University of Münster