Deoxyestrone-based lipofection agents with solution- and solid-state emission properties

Huber A.; Koch J.; Rudolph K.; Höing A.; Rizzo F.; Knauer S.K.; Voskuhl J.

Zusammenfassung

In this contribution, three deoxyestrone-based emissive lipofection agents are reported. Because of a centrally incorporated terephthalonitrile motif, these ligands can be classified as solution and solid-state emitters (SSSEs). With the attachment of tobramycin, these amphiphilic structures are able to form lipoplexes, mediating gene transfection of HeLa and HEK 293T cells.