Depression and Anxiety in Heart Transplant Recipients: Prevalence and Impact on Post-Transplant Outcomes.

Alyaydin, E; Sindermann, JR; Köppe, J; Gerss, J; Dröge, P; Ruhnke, T; Günster, C; Reinecke, H; Feld, J

Forschungsartikel (Zeitschrift) | Peer reviewed

Zusammenfassung

Background: Depression and anxiety (DA) are common mental disorders in patients with chronic diseases, but the research regarding their prevalence in heart transplantation (HTx) is still limited. Methods: We performed an analysis of the prevalence and prognostic relevance of DA in patients who underwent HTx between 2010 and 2018 in Germany. Data were obtained from Allgemeine Ortskrankenkasse (AOK), which is the largest public health insurance provider. Results: Overall, 694 patients were identified. More than a third of them were diagnosed with DA before undergoing HTx (n = 260, 37.5%). Patients with DA more often had an ischaemic cardiomyopathy (p < 0.001) and a history of previous myocardial infarction (p = 0.001) or stroke (p = 0.002). The prevalence of hypertension (p < 0.001), diabetes (p = 0.004), dyslipidaemia (p < 0.001) and chronic kidney disease (p = 0.003) was higher amongst transplant recipients with DA. Patients with DA were more likely to suffer an ischaemic stroke (p < 0.001) or haemorrhagic stroke (p = 0.032), or develop septicaemia (p = 0.050) during hospitalisation for HTx. Our analysis found no significant differences between the groups with respect to in-hospital mortality. The female sex and mechanical circulatory support were associated with an inferior prognosis. Pretransplant non-ischaemic cardiomyopathy was related to a favourable outcome. Conclusions: DA affect up to a third of the population undergoing HTx, with a greater prevalence in patients with comorbidities. DA are associated with a higher incidence of stroke and septicaemia after HTx.

Details zur Publikation

FachzeitschriftJournal of personalized medicine
Jahrgang / Bandnr. / Volume13
Ausgabe / Heftnr. / Issue5
StatusVeröffentlicht
Veröffentlichungsjahr2023
Sprache, in der die Publikation verfasst istEnglisch
DOI10.3390/jpm13050844
Link zum Volltexthttps://www.mdpi.com/2075-4426/13/5/844
Stichwörterdepression; anxiety; orthotopic heart transplantation; in-hospital mortality; survival

Autor*innen der Universität Münster

Alyaydin, Emyal
Klinik für Kardiologie I
Feld, Jannik
Institut für Biometrie und Klinische Forschung (IBKF)
Gerß, Joachim
Institut für Biometrie und Klinische Forschung (IBKF)
Köppe, Jeanette
Institut für Biometrie und Klinische Forschung (IBKF)
Reinecke, Holger
Klinik für Kardiologie I
Sindermann, Jürgen
Klinik für Kardiologie I