Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.
Zhao, Xiaocheng, Nedvetsky, Pavel, Stanchi, Fabio, Vion, Anne-Clémence, Popp, Oliver, Zühlke, Kerstin, Dittmar, Gunnar, Klussmann, Enno, Gerhardt, Holger
Forschungsartikel (Zeitschrift) | Peer reviewedDetails zur Publikation
Fachzeitschrift: eLife
Jahrgang / Bandnr. / Volume: 8
Ausgabe / Heftnr. / Issue: The cAMP-dependent protein kinase A (PKA) regulates various cellular functions in health and disease. In endothelial cells PKA activity promotes vessel maturation and limits tip cell formation. Here, we used a chemical genetic screen to identify endothelia
Status: Veröffentlicht
Veröffentlichungsjahr: 2019
Stichwörter: angiogenesis, PKA, cAMP, autophagy
Autor*innen der Universität Münster