Studies in Zebrafish and Rat Models Support Dual Blockade of EP2 and EP4 (Prostaglandin E-2 Receptors Type 2 and 4) for Renoprotection in Glomerular Hyperfiltration and Albuminuria [Studien an Zebrafischen und Rattenmodellen unterstützen die duale Blockade von EP2 und EP4 (Prostaglandin-E-2-Rezeptoren Typ 2 und 4) zur Nierenprotektion bei glomerulärer Hyperfiltration und Albuminurie]

Kourpa, Aikaterini; Schulz, Angela; Mangelsen, Eva; Kaiser-Graf, Debora; Koppers, Nils; Stoll, Monika; Rothe, Michael; Bader, Michael; Purfuerst, Bettina; Kunz, Severine; Gladytz, Thomas; Niendorf, Thoralf; Bachmann, Sebastian; Mutig, Kerim; Bolbrinker, Juliane; Panakova, Daniela; Kreutz, Reinhold

Abstract

Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. Upregulation of COX2 (cyclooxygenase 2) and prostaglandin E2 (PGE2) was linked to podocyte damage in GH. We explored the potential renoprotective effects of either separate or combined pharmacological blockade of EP2 (PGE2 receptor type 2) and EP4 (PGE2 receptor type 4) in GH.