Studies in Zebrafish and Rat Models Support Dual Blockade of EP2 and EP4 (Prostaglandin E2 Receptors Type 2 and 4) for Renoprotection in Glomerular Hyperfiltration and Albuminuria [Studien an Zebrafischen und Rattenmodellen unterstützen Duale Blockade von EP2 und EP4 (Prostaglandin E2-Rezeptoren Typ 2 und 4) für die Renoprotektion bei glomerulärer Hyperfiltration und Albuminurie]

Kourpa A, Schulz A, Mangelsen E, Kaiser-Grad D, Koppers N, Stoll M, Rothe M, Bader M, Purfürst B, Kunz S, Gladytz T, Niendorf T, Bachmann S, Mutig K, Bolbrinker J, Panakova D, Kreutz R

Abstract

Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. Upregulation of COX2 (cyclooxygenase 2) and prostaglandin E2 (PGE2) was linked to podocyte damage in GH. We explored the potential renoprotective effects of either separate or combined pharmacological blockade of EP2 (PGE2 receptor type 2) and EP4 (PGE2 receptor type 4) in GH.